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Author: ironjusticeDate: 12 Sep 2008
"Urinary 8-hydroxydeoxyguanosine (8-OH-dG)"
That's the latest marker for increased oxidative stress.
Effect of work conditions and work environments on the formation of 8-
OH-dG in nurses and non-nurse female workers.
Ishihara I, Nakano M, Ikushima M, Hara Y, Yoshimine T, Haraga M,
Nakatani J, Kawamoto R, Kasai H
J UOEH 2008 Sep 1; 30(3):293-308.
The purpose of our study was to examine the effects of job stress
factors on oxidative DNA injuries among female workers.
The levels of urinary 8-hydroxydeoxyguanosine (8-OH-dG) were measured
along with a survey on work conditions and environments.
The result showed that female workers in shift work excreted increased
levels of 8-OH-dG in comparison with the result of those who were
engaged in part time work (P < 0.01).
Moreover, the nurses who marked higher depressive scores excreted
significantly increased levels of urinary 8-OH-dG than the nurses who
scored lower depressive states.
The result revealed a positive correlation between 8-OH-dG levels of
nurses in the 35-45 age group and the individual scores of their
depressive states (r = 0.32, P < 0.05).
Together, it was suggested that a heavy burden of work in addition to
daily domestic roles increases urinary excretion levels of 8-OH-dG.
J UOEH
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