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Menopause TreatmentSubject: Reversing Alzheimers
Author: ironjusticeDate: 21 Jul
Video Released Of Rapid Alzheimer's Improvement After New Immune-based
Treatment
Article Date: 21 Jul 2008 - 3:00 PDT
New research into the treatment of Alzheimer's disease reports
improvement in language abilities using a novel immune-based approach.
A video accompanying the research, published today in the open access
journal BMC Neurology, documents rapid language improvement within
minutes of using this new treatment.
Building on previous work by the same authors, published in BioMed
Central's Journal of Neuroinflammation, this study focuses on the
effect of the anti-tumor necrosis factor-alpha (TNF-alpha) drug,
etanercept, on measures of verbal ability.
TNF-alpha, a critical component of the brain's immune system, normally
finely regulates the transmission of neural impulses in the brain. The
authors hypothesize that elevated levels of TNF-alpha in Alzheimer's
disease interfere with this regulation. To reduce elevated TNF-alpha,
the authors utilized a unique perispinal delivery method to administer
etanercept.
The new BMC Neurology article provides preliminary evidence that the
disrupted neural communication seen in Alzheimer's disease may be
reversible.
According to the lead author of the study, Edward Tobinick, "There are
limitations to the data presented; the clinical trial was open label,
and not controlled. These caveats notwithstanding, the scientific
rationale for the further investigation of anti-TNF-alpha treatment of
Alzheimer's disease is compelling. In addition, family members,
independent neurologists, and other independent observers have
confirmed the clinical, cognitive, and behavioral improvement noted".
Disruption of language function, such as the ability to find words, is
a common symptom in advancing Alzheimer's disease, and this BMC
Neurology article is one of the first to suggest the possibility of a
new therapeutic approach that may address these symptoms.
The video is available here.
"Rapid improvement in verbal fluency and aphasia following perispinal
etanercept in Alzheimer's disease."
Edward L. Tobinick and Hyman Gross
BMC Neurology
Article available here.
-- The lead author of the study, Edward Tobinick MD, is Director of
the Institute for Neurological Research, a private medical group,
inc., in Los Angeles. Dr. Tobinick has been investigating the role of
TNF in neurological disorders for a decade. His research has provided
new potential insight into the way immune molecules, such as TNF, may
influence the function of the nervous system.
-- BMC Neurology is an open access journal publishing original peer-
reviewed research articles in all aspects of the prevention, diagnosis
and management of neurological disorders, as well as related molecular
genetics, pathophysiology, and epidemiology. BMC Neurology (ISSN
1471-2377) is indexed/tracked/covered by PubMed, MEDLINE, CAS, Scopus,
EMBASE, Thomson Scientific (ISI) and Google Scholar.
-- BioMed Central is an independent online publishing house committed
to providing immediate access without charge to the peer-reviewed
biological and medical research it publishes. This commitment is based
on the view that open access to research is essential to the rapid and
efficient communication of science.
BioMed Centra
http://www.biomedcentral.com
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